Kaon physics with the KLOE detector

In this paper we discuss the recent finalized analyses by the KLOE experiment at DA$\Phi$NE: the CPT and Lorentz invariance test with entangled $K^0 \bar{K}^0$ pairs, and the precision measurement of the branching fraction of the decay ${ K^+} \rightarrow \pi^+\pi^-\pi^+(\gamma)$. We also present the status of an ongoing analysis aiming to precisely measure the $K^{\pm}$ mass

Calcium intake from different food sources in Italian women without and with non-previously diagnosed osteoporosis

An adequate calcium and vitamin D intake may play a role in preventing osteoporosis, but the contribution of the different food sources of calcium with regards to the risk of osteoporosis been barely explored. This observational study evaluated the calcium intake through a food frequency questionnaire in 126 adult women with not previously diagnosed osteoporosis undergoing Dual-energy X-ray Absorptiometry (DXA) to screen for osteoporosis, and to correlate the calcium intake with parameters of bone density, measured by DXA. Total daily calcium intake and daily intake from food were similar among women found to have osteoporosis, osteopenia or normal condition. The main food source was milk and dairy products, while calcium supplementation was consumed by only 14% of subjects, irrespectively from osteoporosis conditions. DXA parameters were not significantly correlated with total daily calcium intake and calcium from food. The present study highlighted no qualitative and quantitative differences in the consumption of food groups contributing to calcium intakes in women with and without osteoporosis

Scanning Probe Microscopy for polymer film characterization in food packaging

Scanning probe microscopy (SPM) is a branch of microscopy allowing characterization of surfaces at the micro-scale by means of a physical probe (with a size of a few microns) raster scanning the sample. SPMs monitor the interaction between such probe and the surface and, depending on the specific physical principles causing the interaction, they allow generation of a quantitative map of topographic properties: geometrical, optical, electrical, magnetic, etc. This is of the greatest interest, in particular whenever functional surfaces have to be characterized in a quantitative manner. The present paper discusses the different applications of Scanning Probe Microscopy techniques for a thorough characterization of polymer surfaces, of specific interest in particular for the case of food packaging applications

A prototype of fine granularity lead-scintillating fiber calorimeter with imaging read out

The construction and tests performed on a smal prototype of lead-scintillating fiber calorimeter instrumented with multianode photomultipliers are reported. The prototype is 15 cm wide, 15 radiation lenghts deep and is made of 200 layers of 50 cm long fibers. One side of the calorimeter has been instrumented with an array of 3 × 5 multianode R8900-M16 Hamamatsu photomultipliers, each segmented with a matrix of 4 × 4 anodes. The read-out granularity is 240 pixels 11 × 11 mm 2 reading about 64 fibers each. They are interfaced to the 6 × 6 mm 2 pixelled photocade with truncated pyramid light guides made of BC-800 plastic, UV transparent. Moreover each photomultiplier provides also the OR information of the last 12 dynodes. This information can be useful for trigger purposes. The response of the individual anodes, their relative gain and cross-talk has been measured with a 404 nm picosecond laser illuminating only a few fibers on the opposite side of the read-out. We also present first results of the calorimeter response to cosmic rays and electron beam data collected at BTF facility in Frascati

Study of MDT calibration constants using H8 testbeam data of year 2004

In year 2004 Atlas performed a long campaign of test beam data taking at the H8 Cern beam. Two sectors of the barrel and endcap regions of the Muon Spectrometer were exposed to the beam and large amount of data were collected in well defined and controlled operating conditions. This allowed a careful study on MDT drift properties. A better understanding of the calibration constants, of their definition and determination and of the criteria for their acceptance has been obtained. Systematic effects and time stability of the constants have also been studied

Vitamin A, cancer treatment and prevention: The new role of cellular retinol binding proteins

Retinol and vitamin A derivatives influence cell differentiation, proliferation, and apoptosis and play an important physiologic role in a wide range of biological processes. Retinol is obtained from foods of animal origin. Retinol derivatives are fundamental for vision, while retinoic acid is essential for skin and bone growth. Intracellular retinoid bioavailability is regulated by the presence of specific cytoplasmic retinol and retinoic acid binding proteins (CRBPs and CRABPs). CRBP-1, the most diffuse CRBP isoform, is a small 15 KDa cytosolic protein widely expressed and evolutionarily conserved in many tissues. CRBP-1 acts as chaperone and regulates the uptake, subsequent esterification, and bioavailability of retinol. CRBP-1 plays a major role in wound healing and arterial tissue remodelling processes. In the last years, the role of CRBP-1-related retinoid signalling during cancer progression became object of several studies. CRBP-1 downregulation associates with a more malignant phenotype in breast, ovarian, and nasopharyngeal cancers. Reexpression of CRBP-1 increased retinol sensitivity and reduced viability of ovarian cancer cells in vitro. Further studies are needed to explore new therapeutic strategies aimed at restoring CRBP-1-mediated intracellular retinol trafficking and the meaning of CRBP-1 expression in cancer patients' screening for a more personalized and efficacy retinoid therapy

Smart magnetic nanovesicles for theranostic application: Preparation and characterization

Nanomedicines are submicrometer-sized carrier materials designed to improve the biodistribution of systemically administered (chemo)therapeutic agents. By delivering pharmacologically active agents more effectively and more selectively to the pathological site nanomedicines aim to improve the balance between the efficacy and the toxicity of systemic (chemo)therapeutic administrations. Nanomedicine formulations have also been used for imaging applications and, in recent years, for theranostic approaches, that is, for systems and strategies in which disease diagnosis and therapy are combined. On the one hand, “classical” drug delivery systems are being co-loaded with both drugs and contrast agents. Actually, nanomaterials with an intrinsic ability to be used for imaging purposes, such as iron-oxide–based magnetic nanoparticles (MNPs), are increasingly being loaded with drugs or alone for combining disease diagnosis and therapy. In this study, non-ionic surfactant vesicles loaded with lipophilic and hydrophilic MNPs have been prepared. Vesicles have been characterized in terms of dimensions, ζ-potential, time stability, bilayer characteristics and overall iron content. The encouraging obtained results confirm that Tween 20 and Span 20 vesicles could be promising carriers for the delivery of hydrophilic and lipophilic MNPs, respectively, thereby prompting various opportunities for the development of suitable theranostic strategies. The analyzed formulations confirm the importance of surfactant chemical-physical characteristics in entrapping the MNPs of different polarity, highlighting the high versatility of niosomal bilayer and structure; property that make them so appealing among drug delivery nanocarriers

Ten years of pluviometric analyses in Italy for civil protection purposes

The concept of climate change has grown in recent decades, influencing the scientific community to conduct research on meteorological parameters and their variabilities. Research on global warming, as well as on its possible economic and environmental consequences, has spread over the last 20 years. Diffused changes in trends have been stated by several authors throughout the world, with different developments observed depending on the continent. Following a period of approximately 40 days of almost continuous rain that occurred from October to November 2019 across the Italian territory and caused several hazards (e.g., floods and landslides), a relevant question for decision-makers and civil protection actors emerged regarding the relative frequencies of given rainfall events in the Warning Hazard Zones (WHZs) of Italy. The derived products of this work could answer this question for both weather and hydrogeological operators thanks to the frequency and spatio-temporal distribution analyses conducted on 10-year daily rainfall data over the entire Italian territory. This work aspires to be an additional tool used to analyse events that have occurred, providing further information for a better understanding of the probability of occurrence and distribution of future events

Scientific basis of nanotechnology, implications for the food sector and future trends

Nanotechnologies are opening up new horizons in almost all scientific and technological fields. Among these, applications of nanotechnologies are expected to bring large benefits and add value to the food and food-related industries through the current regulatory framework whole food chain, from production to processing, safety, packaging, transportation, storage and delivery. Nanotechnology consists in the realization and manipulation of nano-sized matter, the unique properties of which with respect to their bulk counterparts are illustrated and discussed. Then, the main tools and techniques routinely used in nanotechnology for the nanoscale characterization of food matrices as well as for the analytical determination of nanomaterials in food samples are reviewed. Finally, safety and risk assessment issues are discussed and an overview of applications of nanotechnology to the food sector is provided along with a description of th

Measurement of neutron detection efficiency between 22 and 174 MeV using two different kinds of Pb-scintillating fiber sampling calorimeters

We exposed a prototype of the lead-scintillating fiber KLOE calorimeter to neutron beam of 21, 46 and 174 MeV at The Svedberg Laboratory, Uppsala, to study its neutron detection efficiency. This has been found larger than what expected considering the scintillator thickness of the prototype. %To check our method, we measured also the neutron %detection efficiency of a 5 cm thick NE110 scintillator. We show preliminary measurement carried out with a different prototype with a larger lead/fiber ratio, which proves the relevance of passive material to neutron detection efficiency in this kind of calorimeters